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Genes Dev. 2008 Oct 15;22(20):2743-9. doi: 10.1101/gad.1732108.

Histone H2B ubiquitination: the cancer connection.

Author information

  • 1Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA. Joaquin.espinosa@colorado.edu

Abstract

Post-translational modifications of histones play a critical role in gene expression control. Ultimately, cancer is a disease of aberrant gene expression. Accordingly, several histone-modifying enzymes have been described as proto-oncogenes or tumor suppressors. Recent reports, including one from Shema and colleagues (pp. 2664- 2676) in the October 1, 2008, issue of Genes and Development, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development.

PMID:
18923072
PMCID:
PMC2751279
DOI:
10.1101/gad.1732108
[PubMed - indexed for MEDLINE]
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