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J Clin Microbiol. 2008 Dec;46(12):4083-6. doi: 10.1128/JCM.01408-08. Epub 2008 Oct 15.

Simple disk-based method for detection of Klebsiella pneumoniae carbapenemase-type beta-lactamase by use of a boronic acid compound.

Author information

1
Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA. doiy@dom.pitt.edu

Abstract

A disk potentiation method using carbapenems as substrates and 3-aminophenyl boronic acid as an inhibitor was evaluated for the detection of Klebsiella pneumoniae carbapenemase (KPC)-type beta-lactamases. When combined with nonsusceptibility to ertapenem, the method was easy to perform and reliably differentiated isolates producing KPC-type beta-lactamases from those producing other types of beta-lactamases.

PMID:
18923005
PMCID:
PMC2593264
DOI:
10.1128/JCM.01408-08
[Indexed for MEDLINE]
Free PMC Article

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