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Future Oncol. 2008 Oct;4(5):647-60. doi: 10.2217/14796694.4.5.647.

Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology.

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  • 1Département Endocrinologie Métabolisme et Cancer, Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France.

Abstract

The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in human hepatocellular carcinoma. Several laboratories have shown that the Wnt/beta-catenin pathway plays an essential role in all phases of liver development and maturation, and is required for the metabolic function of this organ. In this review, we summarize current knowledge regarding the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver biology, and the possibilities for developing new therapeutic interventions based on this knowledge.

PMID:
18922122
DOI:
10.2217/14796694.4.5.647
[PubMed - indexed for MEDLINE]
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