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Clin Endocrinol (Oxf). 1991 Jul;35(1):93-6.

Association between autoimmune thyroid disease and familial Alzheimer's disease.

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1
Department of Medicine, King's College School of Medicine, London, UK.

Abstract

OBJECTIVE:

To determine the prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and to ascertain whether there is any evidence for genetic linkage between the two conditions.

DESIGN:

Retrospective study of Familial Alzheimer's Disease kindreds.

PATIENTS:

Seventy affected and unaffected family members from 12 kindreds.

MEASUREMENTS:

Anti-thyroglobulin and anti-microsomal autoantibody status was determined using an enzyme-linked immunosorbent assay. Thyrotrophin levels were determined by an immunoradiometric assay.

RESULTS:

Of the family members, 41.4% had evidence of autoimmune thyroid disease, with significant co-segregation between the presence of thyroid autoantibodies and the development of Alzheimer's disease (P less than 0.01).

CONCLUSIONS:

This study demonstrates a very high prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and suggests that a genetic factor contributing towards the development of autoimmune thyroid disease may be located on chromosome 21 within close proximity to the Familial Alzheimer's Disease gene.

[Indexed for MEDLINE]

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