Format

Send to

Choose Destination
Trends Genet. 1991 Jul;7(7):230-5.

Control of ColE1 plasmid replication by antisense RNA.

Author information

1
Department of Biology, II University of Rome Tor Vergata, Italy.

Abstract

One of the two major classes of regulatory strategies that control plasmid copy number involves recognition via base pairing between two plasmid-encoded complementary RNAs. The detailed analysis of this control circuitry has revealed some features of regulatory mechanisms based on RNA-RNA interaction that distinguish them from those based on protein-nucleic acid interaction. These features provide a framework with which to understand other regulatory mechanisms based on RNA-RNA interaction, and will aid in the design of efficient artificial antisense RNA systems.

PMID:
1887504
DOI:
10.1016/0168-9525(91)90370-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center