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Mini Rev Med Chem. 2008 Oct;8(12):1285-90.

Therapeutic potential of Voltage gated Calcium channels.

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  • 1Centre for Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Punjab, India. cmohan@niper.ac.in

Abstract

Voltage-gated Calcium channels (VGCCs) play important roles in neurotransmitter release, excitation-contraction coupling, hormone secretion, and a variety of other physiological processes. Currently, there exist ion channel therapeutics for anxiety, epilepsy, hypertension, insomnia and pain. There is limited amount of study in this area despite their relevance to human disease and VGCCs remain considerably underexploited. The present review mainly focuses on calcium channel blockers (CCBs), especially for L-type channels and T-type channels, and therein lie some of the opportunities and advantages associated with VGCCs as drug targets.

PMID:
18855741
[PubMed - indexed for MEDLINE]
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