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Nat Rev Neurosci. 2008 Nov;9(11):813-25. doi: 10.1038/nrn2501. Epub 2008 Oct 15.

Silent synapses and the emergence of a postsynaptic mechanism for LTP.

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1
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94143-2140, USA.

Erratum in

  • Nat Rev Neurosci. 2009 Mar;10(3):242.

Abstract

Silent synapses abound in the young brain, representing an early step in the pathway of experience-dependent synaptic development. Discovered amidst the debate over whether long-term potentiation reflects a presynaptic or a postsynaptic modification, silent synapses--which in the hippocampal CA1 subfield are characterized by the presence of NMDA receptors but not AMPA receptors--have stirred some mechanistic controversy of their own. Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity.

PMID:
18854855
PMCID:
PMC2819160
DOI:
10.1038/nrn2501
[Indexed for MEDLINE]
Free PMC Article
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