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Kidney Int. 2008 Nov;74(9):1112-4. doi: 10.1038/ki.2008.420.

Candesartan and renal protection: more than blocking angiotensin type 1 receptor?

Author information

1
Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

Abstract

Chen et al. show that candesartan (Cand) displays an antioxidant action independent of angiotensin type 1 receptor (AT1R) blockade that translates into a superior renoprotection of chronic renal inflammation. The peculiarity of Cand in combining AT1R-blocking activity and an antioxidant action could have important theoretical implications for therapy.

PMID:
18854846
DOI:
10.1038/ki.2008.420
[Indexed for MEDLINE]
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