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Cell. 2008 Oct 3;135(1):18-20. doi: 10.1016/j.cell.2008.09.021.

OMA-gosh, where's that TAF?

Author information

1
Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA. keith.blackwell@joslin.harvard.edu

Abstract

How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.

PMID:
18854150
DOI:
10.1016/j.cell.2008.09.021
[Indexed for MEDLINE]
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