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Dev Cell. 2008 Oct;15(4):491-2. doi: 10.1016/j.devcel.2008.09.014.

Size matters (but so does time), and it's OK to be different.

Author information

1
Department of Biology, Duke University, Durham, NC 27708, USA. hfn@duke.edu

Abstract

In this issue of Developmental Cell, Layalle et al. reveal new insights into how nutrition controls body size in Drosophila. Nutrition specifically affects the activity of target of rapamycin (TOR) in the prothoracic gland. Under low-nutrition conditions, TOR suppresses ecdysone secretion--which otherwise terminates larval development--thereby prolonging growth and allowing larvae to still attain a near-normal body size.

PMID:
18854132
DOI:
10.1016/j.devcel.2008.09.014
[Indexed for MEDLINE]
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