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Mol Vis. 2008;14:1815-8. Epub 2008 Sep 30.

Tumor necrosis factor alpha-308 gene polymorphism and pseudoexfoliation glaucoma.

Author information

1
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey. oyatekeli@tr.net

Abstract

PURPOSE:

To investigate the possible association between tumor necrosis factor alpha (TNF-alpha)-308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma.

METHODS:

One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-alpha-308 was genotyped by polymerase chain reaction and restriction endonuclease analysis.

RESULTS:

We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR=2.88, 95% CI 1.15-7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p=0.023).

CONCLUSIONS:

Our results suggest that TNF-alpha-308 G/A genotype is not associated with PEX glaucoma. The -308G/A variant may be a possible protective factor against PEX.

PMID:
18852869
PMCID:
PMC2565691
[Indexed for MEDLINE]
Free PMC Article
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