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Nat Rev Genet. 2008 Nov;9(11):819-30. doi: 10.1038/nrg2468.

Metabolic syndrome: from epidemiology to systems biology.

Author information

1
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. jlusis@mednet.ucla.edu

Abstract

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.

PMID:
18852695
PMCID:
PMC2829312
DOI:
10.1038/nrg2468
[Indexed for MEDLINE]
Free PMC Article
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