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J Cell Biol. 2008 Oct 20;183(2):181-6. doi: 10.1083/jcb.200805182. Epub 2008 Oct 13.

Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines.

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1
Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

In the canonical model of membrane fusion, the integrity of the fusing membranes is never compromised, preserving the identity of fusing compartments. However, recent molecular simulations provided evidence for a pathway to fusion in which holes in the membrane evolve into a fusion pore. Additionally, two biological membrane fusion models-yeast cell mating and in vitro vacuole fusion-have shown that modifying the composition or altering the relative expression levels of membrane fusion complexes can result in membrane lysis. The convergence of these findings showing membrane integrity loss during biological membrane fusion suggests new mechanistic models for membrane fusion and the role of membrane fusion complexes.

PMID:
18852300
PMCID:
PMC2568015
DOI:
10.1083/jcb.200805182
[Indexed for MEDLINE]
Free PMC Article
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