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Hum Mol Genet. 2008 Oct 15;17(R2):R122-8. doi: 10.1093/hmg/ddn288.

Practical aspects of imputation-driven meta-analysis of genome-wide association studies.

Author information

1
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School-Partners Healthcare Systems Center for Genetics and Genomics, Boston, MA 02115, USA. pdebakker@rics.bwh.harvard.edu

Abstract

Motivated by the overwhelming success of genome-wide association studies, droves of researchers are working vigorously to exchange and to combine genetic data to expediently discover genetic risk factors for common human traits. The primary tools that fuel these new efforts are imputation, allowing researchers who have collected data on a diversity of genotype platforms to share data in a uniformly exchangeable format, and meta-analysis for pooling statistical support for a genotype-phenotype association. As many groups are forming collaborations to engage in these efforts, this review collects a series of guidelines, practical detail and learned experiences from a variety of individuals who have contributed to the subject.

PMID:
18852200
PMCID:
PMC2782358
DOI:
10.1093/hmg/ddn288
[Indexed for MEDLINE]
Free PMC Article

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