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Nat Genet. 2008 Nov;40(11):1282-4. doi: 10.1038/ng.255. Epub 2008 Oct 12.

Male-pattern baldness susceptibility locus at 20p11.

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1
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.

Abstract

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

PMID:
18849991
PMCID:
PMC2672151
DOI:
10.1038/ng.255
[Indexed for MEDLINE]
Free PMC Article
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