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J Trauma. 2008 Oct;65(4):849-51. doi: 10.1097/TA.0b013e3181581f81.

Levothyroxin inhibits heterotopic ossification: an experimental study in rabbits.

Author information

1
Shiraz University of Medical Sciences, Shiraz, Iran. Namazih@sums.ac.ir

Abstract

BACKGROUND:

Heterotopic ossification is a common complication of surgery or trauma.

OBJECTIVE:

To investigate the efficacy of levothyroxin in inhibition of heterotopic ossification.

METHODS:

Heterotopic ossification was induced in 36 rabbits in three identical groups by injecting 2 mL of bone marrow in right thigh. To prevent heterotopic ossification, levothyroxin (20 microg/kg) was administered orally daily for 4 weeks to two groups of adult rabbits: group A (preload)--starting 1 week preceding bone marrow injection; group B--started on day of injection; and group C--control group (no levothyroxin) in a rabbit model. After 5 weeks the rabbits were evaluated by radiographs for evidence of ossification. At the end of the study histologic samples were taken from all the thighs.

RESULTS:

Imaging and histologic studies showed, with statistical significance, almost complete prevention of heterotopic ossification in group A (preload) and a marked decrease in group B, when compared with the controls.

CONCLUSIONS:

Levothyroxin demonstrated efficacy in preventing heterotopic ossification.

PMID:
18849801
DOI:
10.1097/TA.0b013e3181581f81
[Indexed for MEDLINE]

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