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Rev Med Interne. 2009 Feb;30(2):176-8. doi: 10.1016/j.revmed.2008.04.015. Epub 2008 Oct 11.

[Thyroid involvement in Wegener's granulomatosis: a case report].

[Article in French]

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Service de m├ędecine interne, CHU Farhat-Hached, avenue Ibn-Eljazzar, 4000 Sousse, Tunisie.


Wegener's granulomatosis is a systemic necrotizing vasculitis affecting small to medium-sized vessels, characterized by involvement of the upper airways, lungs and kidneys. Endocrine involvement, particularly the thyroid gland is extremely rare. We report a 56-year-old woman presenting a limited form of Wegener's granulomatosis with the following clinical manifestations: sinusitis, pulmonary nodules, diabetes insipidus and a cold thyroid nodule. A right hemithyroidectomy was performed and the histopathological examination revealed a necrotizing vasculitis surrounded by granulomatous lesions. She was treated by corticosteroids without immunosuppressive therapy with a favourable outcome.

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