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Curr Opin Genet Dev. 2008 Dec;18(6):521-9. doi: 10.1016/j.gde.2008.09.003. Epub 2008 Oct 9.

Toward a systems-level understanding of developmental regulatory networks.

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1
Laboratory of Developmental Systems Biology, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

Abstract

Developmental regulatory networks constitute all the interconnections among molecular components that guide embryonic development. Developmental transcriptional regulatory networks (TRNs) are circuits of transcription factors and cis-acting DNA elements that control expression of downstream regulatory and effector genes. Developmental networks comprise functional subnetworks that are deployed sequentially in requisite spatiotemporal patterns. Here, we discuss integrative genomics approaches for elucidating TRNs, with an emphasis on those involved in Drosophila mesoderm development and mammalian embryonic stem cell maintenance and differentiation. As examples of regulatory subnetworks, we consider the transcriptional and signaling regulation of genes that interact to control cell morphology and migration. Finally, we describe integrative experimental and computational strategies for defining the entirety of molecular interactions underlying developmental regulatory networks.

PMID:
18848887
PMCID:
PMC2704888
DOI:
10.1016/j.gde.2008.09.003
[Indexed for MEDLINE]
Free PMC Article
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