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Curr Opin Microbiol. 2008 Oct;11(5):401-8. doi: 10.1016/j.mib.2008.09.008. Epub 2008 Oct 24.

Therapeutic potential of type A (I) lantibiotics, a group of cationic peptide antibiotics.

Author information

1
Mississippi State University, Department of Biological Sciences, Mississippi State, MS 39762, USA. jls859@msstate.edu

Abstract

Type A (I) lantibiotics are cationic antimicrobial peptides that have a potential usefulness in treating infectious diseases. They are known to have a potent and broad spectrum of activity, an insignificant cytotoxicity, and demonstrated efficacy in animal infection models, suggesting therapeutic potential. In this review, topics pertaining to their basic structure, mode of bactericidal activity, pharmacology, and methods of manufacture are described.

PMID:
18848642
PMCID:
PMC2603291
DOI:
10.1016/j.mib.2008.09.008
[Indexed for MEDLINE]
Free PMC Article

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