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Vaccine. 2008 Dec 9;26(52):6975-9. doi: 10.1016/j.vaccine.2008.09.052. Epub 2008 Oct 9.

Vaccination coverage and awareness of infectious risks in patients with an absent or dysfunctional spleen in the Netherlands.

Author information

1
Department of Internal Medicine, St. Antonius Hospital, 3430 EM Nieuwegein, The Netherlands.

Abstract

OBJECTIVE:

To evaluate the current practice to prevent infections in patients with an absent or dysfunctional spleen in a part of the Netherlands. To measure serum antibody levels against Streptococcus pneumoniae and Haemophilus influenzae type b.

DESIGN:

Observational study of vaccination coverage by analysis of questionnaires and serum antibody levels.

SETTING:

Primary care practices in the Utrecht area of the Netherlands, catchment area 750,000 inhabitants, period 2006-2007.

PARTICIPANTS:

One hundred and thirty adult patients with an absent or dysfunctional spleen.

MAIN OUTCOME MEASURES:

Percentage of patients informed about infectious risks and aware of the timely use of antimicrobial prophylaxis. Vaccine coverage against S. pneumoniae, H. influenzae type b and Neisseria meningitidis. Levels of serum antibodies against S. pneumoniae and H. influenzae type b.

RESULTS:

Fifty-six patients (43%) have not received up-to-date information about the infectious risks associated with their condition; 65 patients (50%) are not aware of the need to contact a physician immediately in case of high fever; 37 patients (28%) are keeping antimicrobial prophylaxis at home. Pneumococcal vaccination has been administered within the last 5 years to 103 of 130 patients, antibody levels above the threshold of > or =0.35microg/mL are found in 83 of the 101 patients (data lacking in 2 patients). Complete coverage against S. pneumoniae is only 64% (83/130). A minority of patients (respectively 32% and 27%) has been vaccinated against H. influenzae type b and N. meningitidis.

CONCLUSIONS:

Vaccination coverage and education about infectious risks in patients with an absent or dysfunctional spleen can be improved markedly in the Netherlands.

PMID:
18848594
DOI:
10.1016/j.vaccine.2008.09.052
[Indexed for MEDLINE]

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