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Soc Cogn Affect Neurosci. 2008 Sep;3(3):290-7. doi: 10.1093/scan/nsn029.

Group comparisons: imaging the aging brain.

Author information

1
Department of Psychology, Stanford University, CA 94305-2130, USA. glarkin@stanford.edu

Abstract

With the recent growth of functional magnetic resonance imaging (fMRI), scientists across a range of disciplines are comparing neural activity between groups of interest, such as healthy controls and clinical patients, children and young adults and younger and older adults. In this edition of Tools of the Trade, we will discuss why great caution must be taken when making group comparisons in studies using fMRI. Although many methodological contributions have been made in recent years, the suggestions for overcoming common issues are too often overlooked. This review focuses primarily on neuroimaging studies of healthy aging, but many of the issues raised apply to other group designs as well.

KEYWORDS:

ROI; aging; functional magnetic resonance imaging; group studies; hemodynamics; spatial normalization

PMID:
18846241
PMCID:
PMC2563421
DOI:
10.1093/scan/nsn029
[Indexed for MEDLINE]
Free PMC Article
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