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J Clin Microbiol. 2008 Nov;46(11):3788-90. doi: 10.1128/JCM.01427-08. Epub 2008 Sep 24.

Emergence of amantadine-resistant H3N2 avian influenza A virus in South Korea.

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1
College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju 361-763, Republic of Korea.

Abstract

We found a relatively high frequency of unique amantadine-resistant H3N2 and H9N2 avian influenza viruses (Val27Ile on M2 protein) isolated from live poultry markets in South Korea and confirmed that a Val27Ile single substitution in the M2 protein is enough to acquire the amantadine resistance phenotype by using reverse-genetically created human-avian reassortant viruses.

PMID:
18845822
PMCID:
PMC2576612
DOI:
10.1128/JCM.01427-08
[Indexed for MEDLINE]
Free PMC Article

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