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Nutr Rev. 2008 Oct;66(10 Suppl 2):S88-97. doi: 10.1111/j.1753-4887.2008.00092.x.

Nuclear receptors of the enteric tract: guarding the frontier.

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1
The Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9050, USA.

Abstract

In addition to its classical role in mineral homeostasis, the vitamin D receptor has been implicated in diverse physiologic and pathophysiologic processes including immunoregulation and cancer. Interestingly, the vitamin D receptor has been evolutionarily and functionally linked to a select group of nuclear receptors based on a common organism-wide tissue expression profile. These members of the nuclear receptor superfamily, which include the bile acid receptor, xenobiotic receptors, and several orphan nuclear receptors, comprise a transcriptional regulatory network that functions in nutrient uptake, xenobiotic metabolism, and mucosal protection. The major homeostatic functions of the enteric nuclear receptor network are the topic of this review.

PMID:
18844851
PMCID:
PMC2741173
DOI:
10.1111/j.1753-4887.2008.00092.x
[Indexed for MEDLINE]
Free PMC Article
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