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Nutr Rev. 2008 Oct;66(10 Suppl 2):S178-81. doi: 10.1111/j.1753-4887.2008.00102.x.

Vitamin D: criteria for safety and efficacy.

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1
Creighton University, Omaha, Nebraska 68131, USA. rheaney@creighton.edu

Abstract

The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).

[Indexed for MEDLINE]

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