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Phytother Res. 2009 Mar;23(3):308-16. doi: 10.1002/ptr.2620.

Antiamnesic potential of Murraya koenigii leaves.

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1
Department of Pharmacology, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandampalayam (PO), Erode-District, Tamilnadu 638 052, India. vasumpharmacol@yahoo.co.uk

Abstract

Murraya koenigii leaves commonly known as curry patta are added routinely to Indian gravy and vegetarian dishes as a favorite condiment. The effects of Murraya koenigii leaves (MKL) on cognitive functions, total serum cholesterol level and brain cholinesterase activity in young and aged mice fed orally with a diet containing 2%, 4% and 8% w/w of MKL for 30 days consecutively, were investigated. The memory scores were measured using various exteroceptive and interoceptive behavioral models. The MKL diets produced a significant dose-dependent improvement in the memory scores of young and aged mice and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Also, brain cholinesterase activity and total cholesterol levels were reduced by the MKL diets. The underlying mechanism of action for the observed nootropic effect may be attributed to pro-cholinergic activity and a cholesterol lowering property. Therefore, it would be worthwhile to investigate specifically the therapeutic potential of MKL in the management of Alzheimer patients.

PMID:
18844259
DOI:
10.1002/ptr.2620
[Indexed for MEDLINE]
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