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J Rheumatol. 2008 Dec;35(12):2313-5. Epub 2008 Oct 1.

Circulating dickkopf-1 and radiological progression in patients with early rheumatoid arthritis treated with etanercept.

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1
INSERM Research Unit 664, Lyon, France. patrick.garnero@synarc.com

Abstract

OBJECTIVE:

Dickkopf-1 (Dkk-1) regulates bone remodeling in animal models of inflammatory arthritis, but its role in patients with rheumatoid arthritis (RA) remains unclear.

METHODS:

Baseline circulating Dkk-1 was measured in 113 patients with RA (< 3 yrs) who received etanercept (10 or 25 mg twice/week, n = 63) or methotrexate alone (n = 40) for 1 year. Progression was assessed by changes in radiological Sharp score.

RESULTS:

Increased Dkk-1 was associated with a higher risk of progression of bone erosion, independently of age, sex, baseline radiological damage, C-reactive protein, and disease activity in patients treated with etanercept.

CONCLUSION:

Dkk-1 may be an important mediator of bone erosion in patients with RA.

PMID:
18843784
[Indexed for MEDLINE]
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