Nonrandom t(1;22)(p12-p13;q13) in acute megakaryocytic malignant proliferation

Cancer Genet Cytogenet. 1991 Jul 15;54(2):239-43. doi: 10.1016/0165-4608(91)90213-e.

Abstract

A case of acute megakaryocytic leukemia (M7) and one of acute myeloid hemopathy affecting megakaryocytic and erythrocytic cell lineages in infants are reported. Both patients had t(1;22)(p12-p13;q13). This translocation was previously observed in a congenital M7 leukemia. These studies suggest that t(1;22) translocation can be nonrandom in M7.

Publication types

  • Case Reports

MeSH terms

  • Chromosome Banding
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 22*
  • Female
  • Humans
  • Infant
  • Leukemia, Megakaryoblastic, Acute / genetics*
  • Male
  • Translocation, Genetic