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Infez Med. 2008 Sep;16(3):121-9.

[The use of bundles in clinical practice].

[Article in Italian]

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Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Rome, Italy.


A bundle is a small, straightforward set of scientifically grounded elements (generally three to five) that, when implemented together, result in better outcomes than when implemented individually. Bundles have found their greatest application in the prevention of Healthcare-Associated Infections (HAIs). The bundles examined concern the prevention of VAP for patients undergoing mechanical ventilation, the prevention of BSI CVC, the prevention of surgical side infection (SSI), the prevention of catheter-associated urinary tract infections, the prevention of infection by Clostridium difficile and the treatment of sepsis. Studies show a reduction in mortality rates, infection rates and in the length of hospital stay. Some studies have low statistical significance due to the small number of patients examined, and future studies will be needed to confirm these results.

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