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Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16039-44. doi: 10.1073/pnas.0807010105. Epub 2008 Oct 8.

Electrophysiological correlates of the brain's intrinsic large-scale functional architecture.

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1
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. bhea@wustl.edu

Abstract

Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

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PMID:
18843113
PMCID:
PMC2564983
DOI:
10.1073/pnas.0807010105
[Indexed for MEDLINE]
Free PMC Article
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