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Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073. Epub 2008 Sep 24.

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.

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1
Medicinal Chemistry, Sunesis Pharmaceuticals, South San Francisco, CA 94080, USA. ichoong2@gmail.com

Abstract

The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.

PMID:
18842409
DOI:
10.1016/j.bmcl.2008.09.073
[Indexed for MEDLINE]
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