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Br J Cancer. 2008 Nov 4;99(9):1506-10. doi: 10.1038/sj.bjc.6604701. Epub 2008 Oct 7.

Sex-specific risk factor profile in oesophageal adenocarcinoma.

Author information

1
Unit of Esophageal and Gastric Research (ESOGAR), Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. hedvig-elisabet.lofdahl.348@student.ki.se

Abstract

A nationwide Swedish case-control study of 388 men and 63 women with adenocarcinoma of the oesophagus and gastro-oesophageal function and 676 men controls and 140 women investigated whether sex differences in aetiology contribute to male predominance. Compared with men, women seemed more vulnerable to reflux (odds ratio (OR)=4.6, 95% confidence interval (CI)=2.0-10.5 vs OR=3.4, 95% CI=2.5-4.6), obesity (OR=10.3, 95% CI=2.6-42.3 vs OR=5.4, 95% CI=2.6-10.8) and smoking (OR=5.3, 95% CI=2.0-14.1 vs OR=2.8, 95% CI=1.9-4.2), less harmed by low intake of fruit and vegetables (OR=0.9, 95% CI 0.3-2.4 vs OR=1.6, 95% CI=1.1-2.2) and less protected by Helicobacter pylori infection (OR=0.5, 95% CI=0.3-0.8 vs OR=1.6, 95% CI=0.5-5.4).

PMID:
18841152
PMCID:
PMC2579703
DOI:
10.1038/sj.bjc.6604701
[Indexed for MEDLINE]
Free PMC Article

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