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J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):726-30. doi: 10.1111/j.1447-0756.2008.00916.x.

Ovarian large cell neuroendocrine carcinoma.

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Department of Reproductive Pathophysiology and Obstet-Gynecology, Kagoshima University, Sakuragaoka, Kagoshima, Japan.


Ovarian large cell neuroendocrine carcinoma (LCNC) is a rare disease that is commonly associated with a surface epithelial and germ cell neoplasm component. A 46-year-old woman presented with a pelvic mass measuring 15 cm in diameter. She underwent an exploratory laparotomy with resection of the pelvic mass. Diffuse and nodular intra-abdominal disseminations were observed. Stage III LCNC associated with squamous differentiation alone of the right ovary was diagnosed. The patient died of progressive disease 4 months postoperatively despite paclitaxel and carboplatin therapy. Ovarian LCNC associated with squamous differentiation component alone has never been reported, but its prognosis may be poor.

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