Chiral counteranion-aided asymmetric hydrogenation of acyclic imines

Chaoqun Li; Chao Wang; Barbara Villa-Marcos; Jianliang Xiao

doi:10.1021/ja807188s

Chiral counteranion-aided asymmetric hydrogenation of acyclic imines

J Am Chem Soc. 2008 Nov 5;130(44):14450-1. doi: 10.1021/ja807188s. Epub 2008 Oct 8.

Authors

Chaoqun Li¹, Chao Wang, Barbara Villa-Marcos, Jianliang Xiao

Affiliation

¹ Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, UK.

PMID: 18839940
DOI: 10.1021/ja807188s

Abstract

When combined with a chiral phosphate counteranion, a chiral diamine-ligated Ir(III) catalyst displayed excellent enantioselectivities in the asymmetric hydrogenation of a wide range of acyclic imines, affording chiral amines in up to 99% ee.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemical synthesis*
Catalysis
Diamines / chemistry
Hydrogenation
Imines / chemistry*
Iridium / chemistry
Organometallic Compounds / chemistry
Organophosphates / chemistry
Stereoisomerism

Substances

Amines
Diamines
Imines
Organometallic Compounds
Organophosphates
Iridium