Format

Send to

Choose Destination
Am J Hematol. 2008 Dec;83(12):922-6. doi: 10.1002/ajh.21262.

Expansion of hematopoietic stem/progenitor cells.

Author information

1
Department of Pathology, Hebei Medical University, Shijiazhuang, China.

Abstract

Hematopoietic stem/progenitor cells (HSPCs) transplantation is hampered by the low number of stem cells per sample. To tackle this obstacle, several protocols for expansion of HSPCs in vitro are currently in development, such as the use of cytokine cocktails, coculture with mesenchymal stem cells as feeder cells, and cell culture in bioreactors. With the progress in the understanding of the molecular and cellular mechanisms regulating HSPCs maintenance and expansion, more recent approaches have involved transcription regulation, cell cycle regulation, telomerase regulation, and chromatin-modifying agents. The potential clinical application and safety issues relevant to the expanded HSPCs are also discussed in this review.

PMID:
18839435
DOI:
10.1002/ajh.21262
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center