Send to

Choose Destination
Skin Therapy Lett. 2008 Sep;13(7):1-4.

Current concepts in the treatment of recurrent aphthous stomatitis.

Author information

Department of Dermatology, Dessau Medical Center, Dessau, Germany.


The treatment of recurrent aphthous stomatitis (RAS) still remains nonspecific and is based primarily on empirical data. The goals of therapy include the management of pain and functional impairment by suppressing inflammatory responses, as well as reducing the frequency of recurrences or avoiding the onset of new aphthae. For common forms of RAS, standard topical treatment options that provide symptomatic relief include analgesics, anesthetics, antiseptics, anti-inflammatory agents, steroids, sucralfate, tetracycline suspension, and silver nitrate. Dietary modifications may also support therapeutic measures. In resistant cases of benign aphthosis or aphthosis with systemic involvement, appropriate systemic treatment can be selected from a wide spectrum of immunomodulators that include colchicine, prednisolone, cyclosporine A, interferon-a, tumor necrosis factor-a antagonists, antimetabolites, and alkylating agents.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Skin Therapy Letter
Loading ...
Support Center