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Am J Clin Oncol. 2008 Oct;31(5):496-503. doi: 10.1097/COC.0b013e31816d1ca6.

Definitive radiotherapy for prostate cancer.

Author information

1
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA. mendwm@shands.ufl.edu

Abstract

The probability of extraprostatic disease may be estimated based on clinical T-stage, pretreatment prostatic-specific antigen, Gleason score, and percent positive core biopsies. Patients with disease confined to the prostate may be treated with either prostatectomy or radiotherapy (RT). Patients with extraprostatic disease without evidence of distant metastases are best managed with RT. RT consisting of either external beam and/or brachytherapy results in a relatively high likelihood of cure, particularly for those with low- and intermediate-risk disease. The impact of elective nodal RT on survival is unclear. Dose escalation results in improved biochemical relapse-free survival compared with standard dose RT. Androgen deprivation therapy likely improves the probability of disease control in patients with high-risk cancers.

PMID:
18838889
DOI:
10.1097/COC.0b013e31816d1ca6
[Indexed for MEDLINE]

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