Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Gen Psychiatry. 2008 Oct;65(10):1156-65. doi: 10.1001/archpsyc.65.10.1156.

Depression-related variation in brain morphology over 3 years: effects of stress?

Author information

1
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany.

Abstract

CONTEXT:

Results of experimental studies suggest that neuroplastic changes may occur during depressive episodes. These effects have not been confirmed in patients with depression, to our knowledge.

OBJECTIVE:

To examine changes in the brains of patients with major depression vs those of healthy control subjects.

DESIGN:

Prospective longitudinal 3-year study.

SETTING:

Inpatients with major depression were recruited from the Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany, and controls were recruited from the local community.

PARTICIPANTS:

The study included 38 patients with major depression and 30 healthy controls.

MAIN OUTCOME MEASURES:

High-resolution magnetic resonance imaging was performed at baseline and 3 years later. Voxel-based morphometric measurements were estimated from magnetic resonance images, and psychopathologic findings were assessed at baseline, weekly during the inpatient phase, and then after 1, 2, and 3 years.

RESULTS:

Compared with controls, patients showed significantly more decline in gray matter density of the hippocampus, anterior cingulum, left amygdala, and right dorsomedial prefrontal cortex. Patients who remitted during the 3-year period had less volume decline than nonremitted patients in the left hippocampus, left anterior cingulum, left dorsomedial prefrontal cortex, and bilaterally in the dorsolateral prefrontal cortex.

CONCLUSION:

This study supports findings from animal studies of neuroplastic stress-related processes that occur in the hippocampus, amygdala, dorsomedial prefrontal cortex, dorsolateral prefrontal cortex, and anterior cingulum during depressive episodes.

PMID:
18838632
DOI:
10.1001/archpsyc.65.10.1156
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center