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Br J Ophthalmol. 2009 Jan;93(1):38-9. doi: 10.1136/bjo.2008.139626. Epub 2008 Oct 6.

Retinoblastoma: treatment and survival in Great Britain 1963 to 2002.

Author information

1
Childhood Cancer Research Group, University of Oxford, 57 Woodstock Road, Oxford OX2 6HJ, UK. angela.maccarthy@ccrg.ox.ac.uk

Abstract

AIM:

This paper describes the treatment and survival of 1576 children with retinoblastoma in Great Britain diagnosed 1963-2002.

METHODS:

Survival rates were analysed according to period of diagnosis and tumour laterality.

RESULTS:

Survival was calculated by calendar period of diagnosis, 1963-1982 and 1983-2002. For both unilateral and bilateral retinoblastoma, survival improved between the two periods. The survival curves for the two periods were significantly different: for unilateral retinoblastoma p<0.00001, for bilateral p<0.01. For unilateral cases, the estimated 5-year survival rates rose from 85% for those diagnosed in 1963-1967 to 97% for those diagnosed in 1998-2002. The equivalent rates for bilateral cases were 88% and 100%.

CONCLUSION:

Survival rates were already high at the start of the study period. They increased with changes in treatment regimens.

PMID:
18838414
DOI:
10.1136/bjo.2008.139626
[Indexed for MEDLINE]

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