Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cyst Fibros. 2009 Jan;8(1):26-30. doi: 10.1016/j.jcf.2008.07.005. Epub 2008 Oct 5.

Early referral to cystic fibrosis specialist centre impacts on respiratory outcome.

Author information

1
St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium. Patrick.Lebecque@uclouvain.be

Abstract

BACKGROUND:

Published studies concerning the impact of specialist care on lung disease in cystic fibrosis remain limited and most are either biased due to comparison with historical controls and/or underpowered.

METHODS:

In this retrospective multicentric study, data from all CF children fulfilling the following criteria were collected: 1) Age 6-<18 at the end of 2003; 2) diagnosis before 8 y; 3) follow-up in an accredited CF Belgian centre; 4) at least 1 spirometry and respiratory culture available for 2003. Group A included children referred > or =2 years after the diagnosis. Patients from Group A were then matched with a single early referred patient on the basis of 2 criteria: same centre, as closest age as possible (Group B).

RESULTS:

Data from 217 children were collected (Group A: 67/217). Late referred patients had a lower FEV(1) (77.2%+/-22.4 vs 86.7% pred.+/-19.4, p=0.01) and a higher prevalence of Pseudomonas aeruginosa (38.6 vs 17.5%, p<0.05).

CONCLUSION:

In this population of CF children, a delay of 6.1 y (vs 0.1 y) between diagnosis and referral to a specialist clinic resulted in poorer respiratory outcome at age 13.

PMID:
18838309
DOI:
10.1016/j.jcf.2008.07.005
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center