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Mol Cell Endocrinol. 2009 Feb 5;299(1):14-22. doi: 10.1016/j.mce.2008.09.005. Epub 2008 Sep 17.

The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback.

Author information

1
Endocrine Research Unit, Department of Internal Medicine, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Steet SW, Rochester, MN 55905, United States. veldhuis.johannes@mayo.edu

Abstract

Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.

PMID:
18838102
PMCID:
PMC2662347
DOI:
10.1016/j.mce.2008.09.005
[Indexed for MEDLINE]
Free PMC Article

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