Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biomed Mater Res A. 2008 Dec 15;87(4):1113-22. doi: 10.1002/jbm.a.32287.

Hydrogels used for cell-based drug delivery.

Author information

  • 1Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61822, USA.

Abstract

Stem cells, progenitor cells, and lineage-committed cells are being considered as a new generation of drug depots for the sustained release of therapeutic biomolecules. Hydrogels are often used in conjunction with the therapeutic secreting cells to provide a physical barrier to protect the cells from hostile extrinsic factors. Although the hydrogels significantly improve the therapeutic efficacy of transplanted cells, there have been no successful products commercialized based on these technologies. Recently, biomaterials are increasingly designed to provide cells with both a physical barrier and an extracellular matrix to further improve the secretion of therapeutic proteins from cells. This review will discuss (1) the cell encapsulation process, (2) the immunogenicity of the encapsulating hydrogel, (3) the transport properties of the hydrogel, (4) the hydrogel mechanical properties, and will propose new strategies to improve the hydrogel and cell interaction for successful cell-based drug delivery strategies.

PMID:
18837425
DOI:
10.1002/jbm.a.32287
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center