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Oncogene. 2008 Oct 6;27(45):5913-9. doi: 10.1038/onc.2008.275.

Cytokine-based transformation of immune surveillance into tumor-promoting inflammation.

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Department of Oncology, Schering-Plough Biopharma (formerly DNAX), Palo Alto, CA 94303, USA.


During the last decade, it has become clear that the mammalian immune system is able to recognize and partially suppress nascent tumors. Human T cells specific to oncogenes and onco-fetal antigens are present in human cancer patients and their tumors. At the same time, molecular links between tumor-associated inflammation and tumor progression have been uncovered, providing an explanation for the long recognized epidemiological link between inflammation and cancer. The synopsis of these findings suggests a new interpretation of tumor immunity. It appears that antigen recognition or antigen-specific T-cell expansion at large is not as profoundly impaired in tumor patients as the correct polarization, the survival and the effector function of tumor-infiltrating T cells. This review will focus on pro-inflammatory cytokines likely to contribute to the deregulation of tumor-specific immunity and its consequences.

[Indexed for MEDLINE]

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