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Nat Methods. 2008 Nov;5(11):935-8. doi: 10.1038/nmeth.1256. Epub 2008 Oct 5.

High-speed, miniaturized fluorescence microscopy in freely moving mice.

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1
James H. Clark Center for Biomedical Engineering and Sciences, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.

Abstract

A central goal in biomedicine is to explain organismic behavior in terms of causal cellular processes. However, concurrent observation of mammalian behavior and underlying cellular dynamics has been a longstanding challenge. We describe a miniaturized (1.1 g mass) epifluorescence microscope for cellular-level brain imaging in freely moving mice, and its application to imaging microcirculation and neuronal Ca(2+) dynamics.

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PMID:
18836457
PMCID:
PMC2828344
DOI:
10.1038/nmeth.1256
[Indexed for MEDLINE]
Free PMC Article
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