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Diabetes Care. 2008 Dec;31(12):2276-8. doi: 10.2337/dc08-0924. Epub 2008 Oct 3.

Differential effects of two isoenergetic meals rich in saturated or monounsaturated fat on endothelial function in subjects with type 2 diabetes.

Author information

1
First Department of Propaedeutic Medicine, Laiko General Hospital, Athens University Medical School, Athens, Greece. ntentol@med.uoa.gr

Abstract

OBJECTIVE:

To examine the acute effects of consumption of monounsaturated (MUFAs) and saturated fatty acids (SAFAs) on endothelial function in subjects with type 2 diabetes.

RESEARCH DESIGN AND METHODS:

A total of 33 participants were examined after consumption of two different isocaloric meals: one rich in MUFA and one rich in SAFA, in the form of extra-virgin olive oil and butter, respectively. Endothelial function was assessed by determination of flow-mediated dilatation (FMD).

RESULTS:

FMD did not change significantly after the MUFA-rich meal but declined after the SAFA-rich meal. The FMD during the experiment, expressed as incremental area under the curve, increased after the MUFA-rich meal by 5.2 +/- 2.5% and decreased after the SAFA-rich meal by 16.7 +/- 6.0% (Delta = -11.5 +/- 6.4%; P = 0.008).

CONCLUSIONS:

Consumption of an SAFA-rich meal is harmful for the endothelium, while a MUFA-rich meal does not impair endothelial function in subjects with type 2 diabetes.

PMID:
18835957
PMCID:
PMC2584179
DOI:
10.2337/dc08-0924
[Indexed for MEDLINE]
Free PMC Article

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