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Blood Rev. 2009 May;23(3):95-104. doi: 10.1016/j.blre.2008.08.001. Epub 2008 Oct 2.

Ferritin for the clinician.

Author information

1
Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston-Salem, NC 27157-1082, USA. mknovich@wfubmc.edu

Abstract

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. Elevated serum and tissue ferritin are linked to coronary artery disease, malignancy, and poor outcomes following stem cell transplantation. Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. Additionally, recent research describes novel functions of ferritin independent of iron storage.

PMID:
18835072
PMCID:
PMC2717717
DOI:
10.1016/j.blre.2008.08.001
[Indexed for MEDLINE]
Free PMC Article

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