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Cancer Cell. 2008 Oct 7;14(4):281-3. doi: 10.1016/j.ccr.2008.09.007.

Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

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1
Department of Genetic Medicine and Development, University of Geneva Medical School, CH-1211 Geneva, Switzerland. ariel.ruizaltaba@unige.ch

Abstract

Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.

PMID:
18835029
DOI:
10.1016/j.ccr.2008.09.007
[Indexed for MEDLINE]
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