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Curr Opin Immunol. 2008 Dec;20(6):663-8. doi: 10.1016/j.coi.2008.09.003. Epub 2008 Oct 17.

Cytokines that regulate autoimmunity.

Author information

1
Discovery Research, Schering-Plough Biopharma (formerly DNAX Research Institute), 901 California Avenue, Palo Alto CA 94304, United States.

Abstract

Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGFbeta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of RORgamma-dependent Th17 cells. IL-23--a member of the IL-12 family--activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when dysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27--another IL-12 family member--plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.

PMID:
18834938
DOI:
10.1016/j.coi.2008.09.003
[Indexed for MEDLINE]

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