Catastrophic antiphospholipid (Asherson's) syndrome

Br J Hosp Med (Lond). 2008 Jul;69(7):384-7. doi: 10.12968/hmed.2008.69.7.30413.

Abstract

Catastrophic antiphospholipid syndrome is characterized by multiple organ involvement developing over a very short period of time, histopathological evidence of multiple small vessel occlusions, and laboratory confirmation of the presence of antiphospholipid antibodies. Knowledge of its treatment is vital as the outcome can be lethal.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Aged
  • Antibiotic Prophylaxis*
  • Anticoagulants / therapeutic use*
  • Antiphospholipid Syndrome / classification
  • Antiphospholipid Syndrome / complications
  • Antiphospholipid Syndrome / drug therapy*
  • Catastrophic Illness
  • Child
  • Early Diagnosis
  • Female
  • Heparin / therapeutic use*
  • Humans
  • Immunoglobulins / therapeutic use
  • Male
  • Middle Aged
  • Multiple Organ Failure / etiology
  • Multiple Organ Failure / prevention & control*
  • Prognosis
  • Treatment Outcome
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Anticoagulants
  • Immunoglobulins
  • Heparin