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Rev Bras Psiquiatr. 2008 Sep;30(3):243-5.

Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes.

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1
Bipolar Disorders Program and Laboratory of Molecular Psychiatry, Hospital de ClĂ­nicas de Porto Alegre, Porto Alegre, RS, Brazil.

Abstract

OBJECTIVE AND METHOD:

There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorder patients during acute mania and in healthy controls.

RESULTS:

Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorder patients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group..

CONCLUSION:

These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.

PMID:
18833425
[Indexed for MEDLINE]
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