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Gut. 2009 Jan;58(1):111-7. doi: 10.1136/gut.2008.157735. Epub 2008 Oct 2.

Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B.

Author information

1
Department of Medicine and Therapeutics, 9/F Prince of Wales Hospital, Shatin, Hong Kong, China.

Abstract

BACKGROUND:

Metabolic syndrome is associated with non-alcoholic steatohepatitis and cryptogenic cirrhosis. Whether metabolic syndrome affects the severity of chronic hepatitis B (CHB) is unclear.

AIM:

We aimed to study the relationship between metabolic syndrome and the risk of liver cirrhosis in patients with CHB.

METHODS:

We prospectively recruited patients with CHB from primary care and hospital clinics for liver stiffness measurement (LSM) with transient elastography to diagnose early cirrhosis. Probable cirrhosis was defined as LSM >or=13.4 kPa. We analysed a subgroup of patients with paired LSM and liver biopsies to validate the accuracy of LSM.

RESULTS:

1466 patients had reliable LSM and 134 (9%) patients had adequate liver biopsy. 188 (13%) patients had metabolic syndrome. Histological liver cirrhosis was present in 32/134 (24%) patients. Histological liver cirrhosis was more common among patients who had metabolic syndrome (38%) versus those who did not (11%, p<0.001). The specificity of probable cirrhosis on LSM for histological cirrhosis was 94%. Probable cirrhosis was present in 187 (13%) patients. Metabolic syndrome was more prevalent in patients with probable cirrhosis (24%) than those without cirrhosis (11%, p<0.001). After adjustment for anthropometric, biochemical and virological factors, metabolic syndrome remained an independent factor associated with probable cirrhosis (odds ratio 1.7, 95% confidence interval (CI) 1.1 to 2.6). The odds ratios of probable cirrhosis were 1.4 (95% CI, 0.9 to 2.3), 2.6 (95% CI, 1.7 to 4.3), 4.1 (95% CI, 2.4 to 7.1), 4.0 (95% CI, 1.9 to 8.4) and 5.5 (95% CI, 1.8 to 16.7) in patients with one, two, three, four and five components of metabolic syndrome, respectively.

CONCLUSION:

Metabolic syndrome is an independent risk factor of liver cirrhosis in CHB.

PMID:
18832522
DOI:
10.1136/gut.2008.157735
[Indexed for MEDLINE]

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